Endocrine Abstracts

Life-long glucocorticoid (GC) treatment is needed in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency in order to replace cortisol deficiency and to control ACTH and consequently androgen levels. Therefore, patients with CAH tend to have an increased risk of metabolic syndrome (MS), probably due to cortisol overexposure, caused by multiple daily doses of conventional GCs, unable to mimic cortisol circadian rhythm. The current study aimed at i...

Generously supported by IPSEN)-->Hyperprolactinemia is reportedly associated with impaired metabolic profile, particularly in patients with concomitant hypogonadism. The current study aimed at investigating the effects of 12 and 24 month-continuous cabergoline (CAB) treatment on metabolic profile in male hyperprolactinemic patients. Thirty-two men with prolactinomas, including 22 with testosterone < 8 nmol/l (HG, 69%) and 10 with...

Background: Several evidences suggested that conventional glucocorticoids (CGCs) used as replacement treatment in adrenal insufficiency (AI) are inadequate to mimic physiological cortisol circadian rhythm (CCR), and that CCR disruption, represented by non-physiological pattern of peaks and troughs and elevated evening GC levels, might be responsible for the increased metabolic and, consequently, cardiovascular risk. It has been demonstrated that once daily dual-release-hydroco...

Obesity is caused by an imbalance between dietary energy intake and expenditure. The expression of dopamine receptors (DRs) in human adipocytes has been already demonstrated. Moreover, the effects of cabergoline, a dopamine agonist, on body weight and glucose homeostasis in obese subjects without hyperprolactinemia has already been reported. The current study investigates the effects of cabergoline on lipid accumulation and on adipogenic factors expression to better define the...

Introduction: Bilateral inferior petrosal sinus sampling (BIPSS) is the test that offers the highest diagnostic accuracy in the differential diagnosis between pituitary and ectopic Cushng’s syndrome (CS). The aim of this study was to compare the diagnostic accuracy of BIPSS performed in the last six years, after the change in the technical procedure with that performed in the past period in Naples centre.Patients and methods: Seventeen patients with...

Background: Vitamin D is an important modulator of cell growth, differentiation and death in normal and neoplastic cells. Its actions are mediated by vitamin D receptor (VDR), which heterodimerizes with nuclear retinoid X receptors (RXRα). Recently, it has been suggested that vitamin D system have a role in male reproduction. The aim of this study was to investigate the VDR and RXRα localization in normal and neoplastic human male reproductive tissues.<p class="a...

Introduction: Anophthalmia/microphthalmia is a rare developmental craniofacial defect often associated to congenital hypopituitarism with GH deficiency and hypogonadism. SOX2 gene plays a key role in embryonic development regulation and heterozygous mutations of this gene, reported only in 14 patients to date, have been associated to anophthalmia/microphthalmia and congenital hypopituitarism in uo to 10% of cases. Therefore, the study of the SOX2 gene can be clinically useful ...

Introduction: Pasireotide normalized or reduced UFC in patients with Cushing’s disease in a large, 12-month study. This analysis evaluates the effects of pasireotide on the signs/symptoms of Cushing’s disease according to the degree of UFC control.Methods: Adult patients (n=162) with persistent/recurrent or de novo Cushing’s disease were randomized to pasireotide 600/900 μg s.c. bid. Dose titration (max: 1200 μg...

Introduction: Hyperprolactinemia is reportedly associated with an impaired metabolic profile, particularly in patients with concomitant hypogonadism. The current study aimed at investigating the effects of short (12 months) and long (60 months) treatment with cabergoline (CAB) on metabolic complications, metabolic syndrome (MS) prevalence and visceral adiposity index (VAI) in hyperprolactinemic patients.Patients and methods: Seventy-one patients (51 F, 2...

Introduction: Generously supported by IPSEN)-->Hyperprolactinemia (HPRL) is associated with an impaired metabolic profile, particularly in patients with hypogonadism. This study aimed to: i) investigate the effects of short and long treatment with cabergoline (CAB) on the prevalence of metabolic syndrome (MS) and insulin sensitivity and ii) to evaluate the impact of gonadal function on metabolic changes, in male patients with HPRL.</...